Phenanthrenes and derivatives
Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 200 MG
Irinotecan hydrochloride trihydrate is a potent topoisomerase I inhibitor known for its antitumor activity. It targets Topoisomerase I, playing a crucial role in cancer research and drug development.
- Inhibits the growth of LoVo and HT-29 cells.
- Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
- Significantly inhibits tumor growth in various in vivo models.
- Shows effectiveness against HT-29 xenografts.
Apexbio Technology LLC Tricosanoic acid 2433-96-7 200mg
Tricosanoic acid (CAS 2433-96-7) is a saturated long-chain fatty acid comprising 23 carbon atoms naturally present in plant oils animal fats and waxes While its precise molecular targets remain to be fully elucidated tricosanoic acid serves as a model compound in studies examining lipid metabolism membrane biophysics and the structural effects of very long-chain saturated fatty acids within biological membranes It is utilized in research exploring fatty acid incorporation lipid signaling pathways and the biophysical properties of lipid bilayers Its applications extend to investigations in metabolic disorders lipidomics and membrane dynamics
Medchemexpress LLC Sch-1473759 hydrochloride | 1094067-13-6 | MFCD18251447 | 99.2% | 463.00 g/mol | C20H27ClN8OS | 200 MG
SCH-1473759 hydrochloride is a small-molecule dual aurora kinase inhibitor used in research to probe cell-cycle regulation and kinase signaling. It potently inhibits Aurora A and Aurora B at low nanomolar concentrations and displays activity against several related kinases.
- Potent dual Aurora A and B inhibition (IC50 = 4 nM and 13 nM).
- Direct binding to Aurora kinases (Kd ≈ 20-30 nM).
- Additional kinase activity including VEGFR2, Src family, Chk1, and IRAK4.
- High purity (≈99.2%) and solid, white to yellow physical form.
- Soluble in DMSO and water with warming; reported in vivo formulation options available.
- Suitable for cell-cycle and kinase signaling research applications.
- Recommended sealed storage; in solvent long-term storage at -80°C.
Apexbio Technology LLC Sinapinic acid 530-59-6 200mg
Sinapinic acid (CAS 530-59-6) is an organic compound commonly utilized as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry where it facilitates the desorption and ionization of proteins and peptides for accurate molecular weight determination The compound s ability to absorb laser energy and promote analyte ionization underpins its effectiveness in proteomics research Additionally sinapinic acid is naturally occurring in propolis contributing to the compound s significance in natural product studies Its primary research applications center on biomolecular analysis and the characterization of protein mixtures
Medchemexpress LLC Azelastine hydrochloride | 79307-93-0 | 99.9% | 200 MG
Azelastine hydrochloride is an antihistamine that acts as a potent and selective histamine 1 (H1) antagonist. It is suitable for research related to allergic rhinitis, asthma, diabetic hyperlipidemia, and SARS-CoV-2. This product is for research use only.
- Potent and selective histamine 1 (H1) antagonist.
- Inhibits HNEpC proliferation, potentially aiding in airway remodeling.
- Upregulates H1R, M1R, and M3R levels in human nasal epithelial cells.
- In diabetic hyperlipidemic rat models, it significantly reduces blood glucose, HbA1c, serum alkaline phosphatase, and osteocalcin.
- Downregulates apolipoprotein B.
- Improves lipid profile (decreasing LDL-c and increasing HDL-c).
- Attenuates calcium deposition and aortic calcification.
Apexbio Technology LLC CVT-313 199986-75-9 200mg
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.17% | 50 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It functions by recruiting the E3 ligase Von Hippel-Lindau, which leads to the ubiquitination and subsequent degradation of BCR-ABL1.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau.
- Induces ubiquitination and subsequent degradation of BCR-ABL1.
- Inhibits cell proliferation with IC50 values of 1.11 μM for WT cells, 1.98 μM for T315I cells, and 0.37 μM for G250E cells.
- Induces the degradation of c-ABL1.
- Inhibits downstream signaling through the STAT5 pathway in K562 and Ba/F3 cells.
Medchemexpress LLC Bcr-Abl1-In-1 | 1488090-21-6 | 99.82% | C18H12F3N3O2 | 100 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be utilized in research concerning diseases related to the central nervous system (CNS).
- Exhibits antiproliferative activity against mouse BaF3 cells expressing BCR-ABL with a GI50 of 69 nM and an IC50 of 75 nM.
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
Medchemexpress LLC Quinacrine dihydrochloride | 69-05-6 | MFCD00012659 | 99.4% | 472.88 | 200 MG
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is an orally bioavailable antimalarial agent with anticancer effects both in vitro and in vivo. It suppresses NF-κB and activates p53 signaling, leading to the induction of apoptosis. It is for research use only and not sold to patients.
- Orally bioavailable antimalarial agent
- Exhibits anticancer effects in vitro and in vivo
- Suppresses NF-κB and activates p53 signaling
- Induces apoptosis
- Increases proapoptotic proteins and decreases antiapoptotic proteins
- Suppresses circulating blast cells in AML models
- Increases median survival time in AML models
Medchemexpress LLC Fullerene-C60 | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g/mol | C60 | 25 MG
Fullerene-C60 is the spherical carbon allotrope C60 supplied as a brown-to-black solid reagent for materials science and biochemical research. The product is characterized by high reported purity and defined storage recommendations to preserve stability; common applications include nanomaterials studies, electron-transfer experiments, and biochemical assays.
- High reported purity: 99.73%.
- Solid, brown to black powder form for convenient handling.
- Molecular weight 720.64 g/mol; formula C60.
- Available in small-mass laboratory quantities for research use.
- Recommended storage: powder at -20°C for long term, 4°C for shorter term.
- Suitable for nanomaterials research, physical chemistry, and biochemical assays.
Apexbio Technology LLC Kojic acid 501-30-4 200mg
Kojic acid (CAS 501-30-4) is a small-molecule inhibitor targeting tyrosinase a key enzyme involved in melanin biosynthesis It is designed to inhibit tyrosinase activity thereby reducing melanin production Kojic acid exerts its biological activity primarily through chelation of copper ions at the active site of tyrosinase In enzymatic assays on mushroom tyrosinase kojic acid demonstrates inhibitory activity with an IC50 typically ranging from 14 to 50 M Based on these pharmacological properties kojic acid holds research potential in hyperpigmentation disorders skin whitening applications and oxidative stress-related experimental models