Phenanthrenes and derivatives
Apexbio Technology LLC TED-347-1MG
TED-347 (CAS No 2378626-29-8) is a promising compound in the field of biomedical research primarily explored in the pharmacological and neurobiological categories Originating from advanced synthetic chemistries its mechanism of action involves modulating key neurotransmitter pathways particularly those associated with GABAergic signaling In in vitro assays TED-347 exhibits potency in the nanomolar to low micromolar range indicating strong affinity for its targets Its applications are extensive often utilized in various cell models to investigate neurological disorders as well as in animal studies for efficacy and safety profiling Moreover TED-347 serves as a valuable tool in drug screening processes allowing researchers to evaluate potential therapeutic agents Experimental concentrations typically depend on the specific research design ensuring versatility across studies
Cayman Chemical Aristolochic Acid C, Purity: ≥95%, CAS: 4849-90-5, 10 mg
An alkaloid; inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively)
Medchemexpress LLC Quinacrine dihydrochloride | 69-05-6 | MFCD00012659 | 99.4% | 472.88 | 200 MG
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is an orally bioavailable antimalarial agent with anticancer effects both in vitro and in vivo. It suppresses NF-κB and activates p53 signaling, leading to the induction of apoptosis. It is for research use only and not sold to patients.
- Orally bioavailable antimalarial agent
- Exhibits anticancer effects in vitro and in vivo
- Suppresses NF-κB and activates p53 signaling
- Induces apoptosis
- Increases proapoptotic proteins and decreases antiapoptotic proteins
- Suppresses circulating blast cells in AML models
- Increases median survival time in AML models
![Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene >=96% (HPLC) | 50-32-8 | MFCD00003602 | 5G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501848405.PNG-250.jpg)
Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene >=96% (HPLC) | 50-32-8 | MFCD00003602 | 5G
Benzo[a]pyrene >=96% (HPLC) | Purity: >=96% (HPLC) | Mol Wt: 252.31 | 50-32-8 | MFCD00003602 | 5G
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 25 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. It induces Bcr-Abl degradation in a ubiquitinproteasome-dependent manner and exhibits antiproliferative activity against K562 cells. It has the potential to study cancer.
- Induces Bcr-Abl degradation.
- Exhibits antiproliferative activity against K562 cells.
- Useful for cancer research.
- Features a 2-oxoethyl linker.
Medchemexpress LLC Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- | 313-67-7 | 341.27 | 1 ML
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- | 313-67-7 | 341.27 | 1 ML
Medchemexpress LLC Aristolochic acid A | 313-67-7 | 341.27 | 100 MG
Aristolochic acid A is the primary component of Aristolochic acids, plant extracts found in various herbal plants of the genus Aristolochia and Asarum. It reduces both activator protein 1 (AP-1) and NF-κB activities and decreases BLCAP gene expression in human cell lines.
- Reduces activator protein 1 (AP-1) activity
- Reduces NF-κB activity
- Decreases BLCAP gene expression in human cell lines
- Found in various herbal plants of genus Aristolochia and Asarum
Sigma Aldrich Fine Chemicals Biosciences Chrysene BCR(R), certified reference material | 218-01-9 | MFCD00003698 | 20MG
Chrysene BCR(R), certified reference material | Mol Wt: 228.29 | 218-01-9 | MFCD00003698 | 20MG
Medchemexpress LLC Aristolochic acid B (aristolochic acid II) | 475-80-9 | 311.25 | 1 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica, forms DNA adducts, and is mutagenic. It exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Orally active major component of aristolochic acid.
- Isolated from plants of the Aristolochica genus.
- Forms DNA adducts and is mutagenic.
- Shows greater carcinogenic risk in vivo than Aristolochic acid I.
- Purity of 99.92%.
- Soluble in DMSO for in vitro studies.
- Specific storage conditions to maintain stability.
Sigma Aldrich Fine Chemicals Biosciences Carnosic acid from Rosmarinus officinalis >=91%, powder | 3650-09-7 | MFCD02259459 | 10MG
Carnosic acid from Rosmarinus officinalis >=91%, powder | Purity: >=91% | Mol Wt: 332.43 | 3650-09-7 | MFCD02259459 | 10MG